ADVANCED MELANOMA  

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ADVANCED SUPERFICIAL SPREADING MELANOMA DISSEMINATED METASTATIC MELANOMA

The image to left shows an avanced SUPERFICIAL SPREADING MELANOMA, covering a skin area of 11*6 CM. At the lesion's periphery, the tumor is still growing progressively, while in the central parts of the tumor area it has undergone PARTIAL TUMOR REGRESSION. This is a common finding in larger-area cases of SUPERFICIAL SPREADING MELANOM, and can be clinically seen by its white color tint within the black tumor area. Microscopic analysis (HISTOLOGY) shows that in these areas of PARTIAL TUMOR REGRESSION tumor cells had been more or less replaced by fibrotic tissue, following an inflammatory reaction within the tumor (which can be detected under the microscope only). While the tumor virtually destroys itself in the center, it nonetheless progressively grows at the periphery, thereby getting more and more malignant.

The image to the right shows the skin aspect of a widely disseminated/metastatic melanoma, originating from a spot on the forefoot. This finding comes along with internal/visceral metastases to the lung, brain, liver, and other organ sites.